This study investigates the effect of blood flow restriction with resistance exercise on functional mobility in pre-frail older adults. It is hypothesized that receiving resistance exercise with blood flow restriction will exhibit better improvement on functional mobility than only receiving resistance exercise in pre-frail older adults.
Participants aged over 65 years old with less than two items positive of Fried frailty phenotype assessment result will be recruited. The participants will be randomly assigned to two training groups, blood flow restriction resistance exercise and traditional resistance exercise. Both groups will receive the training 30 minutes/session, two sessions/week for six weeks. Muscle strength of the lower extremities and functional mobility tests will be used to assess outcomes at pre-training, 3-week after training, post-training, and one-month and two-month follow-up.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
54
Resistance exercise mainly on the lower extremities will be executed by carrying weight according to each participant's tolerance while performing certain movements, such as side step-up, sit-to-stand, and tip-toe-standing.
Blood flow restriction on the thigh of the dominant leg will be used in combination with resistance exercise.
Department of Physical Therapy
Tainan, Taiwan
Change of Timed-Up and Go (TUG) test
Timed-Up and Go test
Time frame: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
Change of 30 seconds sit to stand
30 seconds sit to stand test
Time frame: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
Change of muscle strength of the lower extremities
Muscle strength of bilateral hip flexors, knee extensors, ankle dorsiflexors and plantarflexors
Time frame: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
Change of one-repetition maximum
One-repetiton maximum of side step-ups
Time frame: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
Change of muscle mass
Muscle mass of the upper and lower extremities and trunk
Time frame: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
Change of hand grip strength
Bilateral grip strength
Time frame: Before intervention, 3 and 6 weeks after intervention, and one- and two-month follow ups after intervention
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