In this randomized controlled trial, it was aimed to evaluate the effect of probiotics (chewable tablets) and kefir consumption in the initial periodontal treatment of periodontitis patients on the change of oral microbiota and treatment. In this clinical trial, 36 systemically healthy volunteers who were diagnosed with periodontitis who were admitted to Gazi University Faculty of Dentistry, Department of Periodontology were included. Besides the inclusion criteria, the nutritional habits of the patients were evaluated by questionnaire. For diagnosis, plaque index, gingival index, bleeding on probing, periodontal probing depth and clinical attachment level were examined. Patients were randomly divided into 3 groups; probiotic, kefir and control group. Following the periodontal diagnosis, clinical index records of the patients and subgingival microbial samples were obtained. The supragingival plaque sample was removed and the subgingival microbial dental plaque sample was gently taken with a sterile Gracey curette. In the same session, periodontal initial treatment was started. According to the groups, they were involved simultaneously with the treatment, kefir group was advised to consume kefir as a liquid once a day in 14 days; probiotics group was advised to consume as a chewable tablet once a day in 14 days; the control group was advised without additional food supplements. Periodontal indexes were repeated in the 1st and 3rd months. Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia (T. forsythia), Porphyromonas gingivalis (P. gingivalis), and Treponema denticola (T. denticola).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
36
According to the groups, they were involved simultaneously with the treatment, kefir group was advised to consume kefir as a liquid once a day in 14 days; the probiotics group was advised to consume as a chewable tablet once a day in 14 days; the control group was advised without additional food supplements.
AOÇ Kefir
Food without additional food supplements
Gazi University Faculty of Dentistry
Ankara, Turkey (Türkiye)
Tuğba Şahin
Ankara, Turkey (Türkiye)
Periodontal probing depth
the distance from the gingival margin to pocket base.
Time frame: Baseline
Periodontal probing depth
the distance from the gingival margin to pocket base.
Time frame: 1st month
Periodontal probing depth
the distance from the gingival margin to pocket base.
Time frame: 3rd month
Gingival index
It is an index that shows the severity and quantity of gingival inflammation.
Time frame: Baseline
Gingival index
It is an index that shows the severity and quantity of gingival inflammation.
Time frame: 1st month
Gingival index
It is an index that shows the severity and quantity of gingival inflammation.
Time frame: 3rd month
Microbiological sample
Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia, Porphyromonas gingivalis, and Treponema denticola.
Time frame: Baseline
Microbiological sample
Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia, Porphyromonas gingivalis, and Treponema denticola.
Time frame: 1st month
Microbiological sample
Subgingival plaque samples were taken at baseline and at 3 months and DNA sequencing was performed for Tanneralla forsythia, Porphyromonas gingivalis, and Treponema denticola.
Time frame: 3rd month
Plaque index
It is an index that shows the amount of microbial dental plaque on the teeth.
Time frame: Baseline
Plaque index
It is an index that shows the amount of microbial dental plaque on the teeth.
Time frame: 1st month
Plaque index
It is an index that shows the amount of microbial dental plaque on the teeth.
Time frame: 3rd month
Bleeding on probing
Bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus.
Time frame: Baseline
Bleeding on probing
Bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus.
Time frame: 1st month
Bleeding on probing
Bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus.
Time frame: 3rd month
Clinical attachment level
The clinical attachment level is the distance between the enamel-cementum junction and the gingival sulcus.
Time frame: Baseline
Clinical attachment level
The clinical attachment level is the distance between the enamel-cementum junction and the gingival sulcus.
Time frame: 1st month
Clinical attachment level
The clinical attachment level is the distance between the enamel-cementum junction and the gingival sulcus.
Time frame: 3rd month
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