A Randomised Comparison of Left and Right Sided Approaches to Ablation of the Atrioventricular Junction

East Sussex Hospitals NHS Trust100 enrolled

Overview

This study will compare right sided atrioventricular node ablation to left sided atrioventricular node ablation

Right-sided atrioventricular node ablation has been the initial conventional approach however up to 18.5% of patients require switching to a left sided approach or have a challenging procedure. Previous studies have found that left sided ablation is more efficacious than right-sided ablation requiring less than 5 applications of radiofrequency energy to induce atrioventricular block. This study will compare right sided atrioventricular node ablation to left sided atrioventricular node ablation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Atrial Fibrillation

Interventions

atrioventricular node ablationPROCEDURE

atrioventricular node ablation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age greater than or equal to 18 years * Referred for atrioventricular node ablation for any such indication Exclusion Criteria: * Stroke or transient ischaemic attack (TIA) within 6 months * Myocardial infarction within 6 months * Medical conditions limiting expected survival to \<1 year * Moderate to severe aortic stenosis * History of aortic or mitral valve replacement * Pregnancy or breast feeding women

Locations (1)

Eastbourne District General Hospital

Eastbourne, East Sussex, United Kingdom

RECRUITING

Outcomes

Primary Outcomes

Comparison of total ablation time required to induce complete atrioventricular node block

Time in seconds

Time frame: intraoperative

Secondary Outcomes

Comparison of number of RF applications required to induce complete atrioventricular node block

Time frame: intraoperative

Comparison of total procedure time between the two groups

Time frame: intraoperative

Comparison of radiation exposure between the two groups

Time frame: intraoperative

Comparison of rate of the escape rhythm after ablation in beats/min

Time frame: intraoperative

Comparison of number of patients requiring crossover to each side

Time frame: intraoperative

Comparison of adverse events / complications between each group

Time frame: intraoperative

Comparison of patient comfort of procedure

Central Contacts

Rick Veasey

CONTACT

03001315457 rick.veasey@nhs.net

Data from ClinicalTrials.gov

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