Clinical Relevance of Different Training Intensities in Chronic Heart Failure.

Cairo University45 enrolled

Overview

To determine the efficacy of different aerobic exercise training intensities in patients with chronic heart failure.Forty five eligible male patients with chronic heart failure were randomly assigned into three groups( High intensity , moderate intensity and low intensity)groups .

Forty five eligible male patients with chronic heart failure secondary to ischemic heart disease were selected from National Heart Institute heart failure outpatient clinic , their ages ranged from 50-60 years old and their ejection fraction ranged from 30-40% ,they were randomly assigned into three groups :HIT Group: received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.(n=15) MIT Group: received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months. .(n=15) LIT Group: received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months, Before and after intervention, the following measures were obtained: Echocardiograph parameter (EF%, and left ventricular internal dimension ) , prognostic biomarkers (proBNP), and quality of life .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Chronic Heart Failure

Interventions

Aerobic exercise trainingOTHER

bicycle ergometer exercise training

Eligibility

Sex: MALEMin age: 50 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with following criteria were included : * All patients ages were between 50 - 60 years old * Fractional shortening \< 25% and ejection fraction \< 40% * Sinus rhythm. * Heart Failure due to ischemic heart disease. * New York Heart Association (NYHA) class II-III. * Regular medical treatment. Exclusion Criteria: * Patients with following criteria were excluded : * Chronic heart failure due to other causes * History of pulmonary disease (chronic obstructive lung disease, moderate to severe pulmonary hypertension). * Recent acute coronary syndrome or revascularization (3 months). * Exercise limited by angina or peripheral arterial occlusive disease; * Cerebrovascular or musculoskeletal disease preventing exercise testing or training. * Poorly controlled or exercise-induced cardiac arrhythmias * Logistic problems to attend regular exercise training sessions. Uncontrolled hypertension.

Locations (1)

Faculty of Physical Therapy

Cairo, Egypt

Outcomes

Primary Outcomes

Ejection fraction

represents left ventricular function measured by pulsed echocardiography

Time frame: change from baseline to after 12 weeks

pro-brain natriuretic peptide (proBNP)

biomarker for heart failure measured by analysis of venous samples drawn

Time frame: change from baseline to after 12 weeks

Secondary Outcomes

Minnesota Living With Heart Failure Questionnaire (MLWHF):

Questionnaire for measuring quality of life of heart failure patients

Time frame: change from baseline to after 12 weeks

Data from ClinicalTrials.gov

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