Effects on Glucose Homeostasis of Changes in Plasma Lipoproteins Induced by Nutritional and Pharmacologic Strategies

Azienda Ospedaliero, Universitaria Pisana50 enrolled

Overview

The investigators aim to examine the impact of changes in plasma lipoproteins induced by nutritional and pharmacological interventions on glucose homeostasis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Glucose Metabolism Disorders

Interventions

Intermittent FastingDIETARY_SUPPLEMENT

Intermittent fasting meal pattern

FibratesDRUG

Bezafibrate 400 mg/day

Low-Carbohydrate/High-Protein dietDIETARY_SUPPLEMENT

Low-calorie, low-carbohydrate, high-protein diet

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 18-65 years * both males and females Exclusion Criteria: * acute or chronic conditions influencing glucose and lipid metabolism * pregnancy

Locations (1)

Azienda Ospedaliero-Universitaria Pisana

Pisa, PI, Italy

Outcomes

Primary Outcomes

Glucose tolerance

Glucose tolerance will be measured as the area under the curve of plasma glucose levels in response to a 180-minute 75g oral glucose tolerance test (OGTT)

Time frame: 180 minutes

Data from ClinicalTrials.gov

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