The Sentinel Registry

Inclusion Criteria: * Age 19 and more * Undergoing TAVR with the use of SENTINEL embolic protection device * Higher risk of cerebrovascular embolic events (any of the followings) 1. Bicuspid aortic valve 2. Calcified lesion or atherosclerosis in the ascending aorta and/or aortic arch 3. Heavy calcified aortic valve (Ca. volume \> 500) 4. Chronic kidney disease 5. Prior stroke 6. Stroke risk is strongly anticipated by attending physicians * Compatible carotid and brachiocephalic artery anatomy for SENTINEL device as determined by Multi-Slice Computed Tomography scan or equivalent imaging modality * Agrees to the study protocol and the schedule of clinical follow-up and provides informed, written consent, as approved by the appropriate Institutional Review Board/Ethical Committee of the respective clinical site. Exclusion Criteria: * Vasculature in the right extremity precluding radial or brachial access * Excessive tortuosity in the right radial/brachial/subclavian artery preventing Sentinel System access and insertion * Inadequate circulation to the right extremity as evidenced by signs of artery occlusion (modified Allen's test) or absence of radial/brachial pulse * Hemodialysis shunt, graft, or arterio-venous fistula involving the upper extremity vasculature * Symptomatic or asymptomatic severe occlusive carotid disease requiring concomitant carotid endarterectomy/stenting * Undergone carotid stenting or carotid endarterectomy within the previous 6 weeks * Concurrent medical condition with a life expectancy of less than 1 year