Targeting the Carotid Bodies to Reduce Disease Risk Along the Diabetes Continuum

N/ACompletedNCT05219994

University of Missouri-Columbia22 enrolled

Overview

Our overall goal is to advance our understanding of the contribution of the carotid body chemoreceptors in glucose regulation and the development of type 2 diabetes.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Type 2 Diabetes

Interventions

Hyperoxia ExposureOTHER

2 hours of hyperoxia exposure during OGTT

Normoxia ExposureOTHER

2 hours of normoxia exposure during OGTT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy, * type 2 diabetes * BMI 18-40 kg/m2, * non-pregnant, * non-breastfeeding, * non-nicotine users. Exclusion Criteria: * cardiovascular disease including myocardial infarction, heart failure, coronary artery disease, stroke; * renal or hepatic diseases; * active cancer; * autoimmune diseases; * immunosuppressant therapy; * excessive alcohol consumption (\>14 drinks/week); * current nicotine use; * foot ulcers; * diabetic neuropathy; * medication directly influencing sympathetic nervous system activity

Locations (1)

University of Missouri

Columbia, Missouri, United States

Outcomes

Primary Outcomes

Glucose change in response to OGTT

Time frame: 2 hours post glucose ingestion

Insulin change in response to OGTT

Time frame: 2 hours post glucose ingestion

Data from ClinicalTrials.gov

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