This project assesses the effect of bifocal cross-frequency transcranial alternating current stimulation (tACS) combined with visual training to improve visual recovery and orchestrated oscillatory activity in stroke patients suffering from visual field defects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
Dual site transcranial alternating current stimulation over the primary visual cortex (V1) and the mediotemporal cortex (MT/V5) using two different stimulation frequencies (Alpha and Gamma)
Campus Biotech, EPFL
Geneva, Switzerland
Changes in visual field functions
Comparison of the systematic measurement of the visual field using Humphrey perimetry
Time frame: Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)
Changes in motion discrimination and integration performances
Comparison of the motion coherence threshold extracted from a two forced-choice direction discrimination task
Time frame: Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)
Changes in inter-areal cross-frequency interaction
Comparison of the inter-areal Alpha-Gamma coupling using electroencephalography recordings
Time frame: Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)
Changes in visual tracts integrity
Comparison of the diffusion weigted imaging-based tractography of the main visual tracts
Time frame: Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)
Changes in functional connectivity within the broad visual network
Functional MRI based connectivity analyses using DCM or graph theory will perfomed
Time frame: Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)
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