This is a study to assess if 162 mg of aspirin will decrease rates of preeclampsia in pregnant patients compared to 81 mg of aspirin.
After screening to meet inclusion criteria, pregnant patients at the Family Medicine Clinic will be asked to take 162 mg aspirin daily for 6 months, starting at about 12 weeks gestation and continued until the end of pregnancy. They will be monitored every 4 weeks until week 28, then every 2 weeks until week 36, and then weekly from week 36 on. Participants will be screened at these visits for medication compliance (taking, missed doses, side effects, etc). Patients will be subject to lab work as is routinely indicated for preeclampsia. At the end of the study period, accumulated study data will be compared with historical data from the Family Medicine Clinic on rates of preeclampsia and outcomes in patients taking 81 mg for preeclampsia prevention.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
200
Daily aspirin 162 mg during pregnancy to prevent preeclampsia
UnityPoint Clinic Family Medicine
Peoria, Illinois, United States
RECRUITINGNumber of participants with preeclampsia
Dangerous pregnancy complication characterized by high blood pressure
Time frame: Through study completion, estimated 18 months
Number of participants with eclampsia
new onset of seizures in pregnant woman with preeclampsia
Time frame: Anytime during pregnancy and 3 months post partum
Number of participants with placental abruption
Separation of placenta from the uterus prior to delivery
Time frame: Through study completion, estimated 18 months
Number of participants with post partum hemorrhage
blood loss after delivery
Time frame: Through study completion, estimated 18 months
Number of participants with aplastic anemia
deficiency of all blood cell lines
Time frame: Through study completion, estimated 18 months
Number of participants with agranulocytosis
deficiency of granulocytes
Time frame: Through study completion, estimated 18 months
Number of participants with anaphylaxis
serious allergic reaction
Time frame: Through study completion, estimated 18 months
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