Oleactiv® have previously demonstrated beneficial effects in an animal model of diet-induced atherosclerosis. After a 12-week supplementation, a substantial reduction of aortic fatty streak area has been observed. Also, Oleactiv®-supplemented hamsters displayed significant decrease of both non-HDL-cholesterol and triglycerides levels. Also, phenolic compounds from Oleactiv® demonstrated that increase of cholesterol efflux capacity (CEC) is one of the mechanisms that may explain preventive effect on atheroma development. These effects observed in animals will thus be investigated in human. The main hypothesis of the present study is that phenolic compounds from Oleactiv® may improve LDL oxidability in volunteers with moderate hypercholesterolemia after 3 weeks of consumption.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
26
Food supplements are consumed during 3 weeks by hypercholesterolemic volunteers
Food supplements are consumed during 3 weeks by hypercholesterolemic volunteers
NutrINvest
Lille, France
Change from baseline of LDL oxidability after 3 weeks of food supplement consumption compared to placebo group
LDL oxidability
Time frame: 3 months
Change from baseline of lipid metabolism after 3 weeks of food supplement consumption compared to placebo group
Total cholesterol, HDL, LDL, Triglycerides,
Time frame: 3 months
Change from baseline of lipoproteins size distribution after 3 weeks of food supplement consumption compared to placebo group
Lipoprotein size
Time frame: 3 months
Change from baseline of plasma paraoxonase activity after 3 weeks of food supplement consumption compared to placebo group
Paraoxonase activity
Time frame: 3 months
Change from baseline of reverse transport of cholesterol after 3 weeks of food supplement consumption compared to placebo group
Reverse transport of cholesterol
Time frame: 3 months
Change from baseline of cholesterol load capacity after 3 weeks of food supplement consumption compared to placebo group
Cholesterol load capacity
Time frame: 3 months
Maximum plasma concentration of phenolic compounds in a 24h-blood collection
Phenolic compounds were measured after food supplement consumption at 7 points (T0, T1h, T2h, T4h, T6h, T10h, T24h).
Time frame: 3 months
Time of complete elimination of phenolic compounds in a 24h-blood collection
Phenolic compounds were measured after food supplement consumption at 7 points (T0, T1h, T2h, T4h, T6h, T10h, T24h).
Time frame: 3 months
Maximum plasma concentration of oxidized LDL in a 24h-blood collection
Oxidized LDL were measured after food supplement consumption at 7 points (T0, T1h, T2h, T4h, T6h, T10h, T24h).
Time frame: 3 months
Maximum concentration of urinary isoprostanes in a 48h-urine collection
Urinary isoprostanes were measured after food supplement consumption at 7 points (from 22h the day before to 8h (T0), T0-6h, T6-10h, T10-14h, T14-24h, T24-32h, T32-48h).
Time frame: 3 months
Change from baseline of carbohydrate metabolism after 3 weeks of food supplement consumption compared to placebo group
glycemia, insulin
Time frame: 3 months
Change from baseline of arterial stiffness after 3 weeks of food supplement consumption compared to placebo group
Arterial stiffness via the Sphygmocor® measuring device
Time frame: 3 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.