Quantitation of Bacteria Associated With Severe Periodontitis by Real -Time PCR Following Application of Diode Laser

Alexandria University50 enrolled

Overview

1. Primary objective To measure the gingival crevicular levels of A.actinomycetemcomitans and P.gingivalis after intra-pocket application of diode laser in severe periodontitis (stage 3 grade C) patients. 2. Secondary objective To compare the levels of the same microorganisms as in cases of diode laser therapy to those after conventional treatment with systemic antibiotic administration in severe periodontitis (stage 3 grade C) patients. 3. to measure clinical parameters probing depth,attachment loss and mobility grade

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Periodontal Pocket

Interventions

medency diode laserDEVICE

intra pocket application of diode laser

spirazole forteDRUG

adminstration of spirazole forte with a dose 17 mg per kg

Eligibility

Sex: ALLMin age: 15 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients of both sexes having severe periodontitis (stage 3 grade C) with interdental clinical attachment loss (CAL) ≥ 5. 2. Patients' age between 15 and 35 years old with rapid bone loss showed by radiograph. 3. Systemically healthy patients. 4. Radiographic bone loss extending to middle or apical third of root. 5. Probing depth (PD) ≥ 6 mm. Exclusion Criteria: 1. Use of antibiotics during the last 3 months. 2. Pregnancy. 3. Any systemic condition that might affect the study. 4. Use of mouthwash containing antimicrobials during the previous 3 weeks. 5. Smoking.

Locations (1)

Amira Hafez

Alexandria, Egypt

Outcomes

Primary Outcomes

Quantitation of Aggrecatibacter .actinomycetemcomitans and porphyromonas gingivalis bacteria

To measure the gingival crevicular levels of A.actinomycetemcomitans and P.gingivalis after intra-pocket application of diode laser in severe periodontitis(stage 3 grade C) patients

Time frame: baseline

Secondary Outcomes

comparing levels of bacteria between test and control groups

To compare the levels of the same microorganisms as in cases of diode laser therapy to those after conventional treatment with systemic antibiotic administration in severe periodontitis ( stage 3 grade C) patients.

Time frame: baseline

Data from ClinicalTrials.gov

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