Drug Use Evaluation of Clindamycin in Critical Care Units in Alexandria Main University Hospital

Alexandria University99 enrolled

Overview

Irrational use of antibiotics is a one of the main health system problems,it leads to antibiotic resistance,increasing antibiotics side effects and the total cost. This study is a medication use evaluation study aims to evaluate intravenous clindamycin prescribing practice in critical care units in Alexandria Main University Hospital.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Infection, Bacterial

Interventions

Clindamycin InjectionDRUG

it is a clindamycin use evaluation study

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults 18 years old or more . * Patients on clindamycin as an empirical treatment. * Patients started clindamycin as an emperical treatment in other departments but the physician approved to continue it in critical care. Exclusion Criteria: * Children (less than 18 years old) * Patients started clindamycin as a defenitive treatment (based on microbiological culture results).

Locations (1)

Faculty of Mdicine

Alexandria, Egypt

Outcomes

Primary Outcomes

the number of prescriptions with appropriate indications of clindamycin will be counted during the retrospective observation of all prescriptions

appropriateness of clindamycin indication will be determined according to IDSA guidelines.

Time frame: 1 month

Secondary Outcomes

the number of prescriptions with duplication of therapy with clindamycin will be counted during the retrospective observation of all prescriptions

duplication of therapy means prescribing of clindamycin concurrently with another antibiotic to target the same microorganism.

Time frame: 1 month

the number of patients who had diarrhea as a main side effect of clindamycin

diarrhea is a main side effect of clindamycin so in the study the number of patients who had diarrhea will be counted during the retrospective observation of all prescriptions

Time frame: 1 month

the number of patients who had severe drug interactions with clindamycin

in the study the number of patients who severe clindamycin drugs interactions will be counted during the retrospective observation of all prescriptions

Time frame: 1 month

Total clindamycin DDD defined daily doses and clindamycin defined daily doses per 1000 patients days.

Defined daily doses measurement of a drug is an indicator put by WHO , it indicates the consumption of this drug in a hospital or a department and defined daily doses per 1000 patients days indicates the consumption of this drug in relation to the total number of patients in a certain period of time.

Time frame: 1 month

to calculate the total cost of clindamycin.

The cost of clindamycin treatment courses of all patients will be calculated in the Egyptian pound

Data from ClinicalTrials.gov

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