To Evaluate the Safety and Tolerability of Human CD19-CD22 Targeted T Cells Injection for Subjects With R/R B-ALL.

Inclusion Criteria: Subjects with Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia: * 18\~70 years old (including cut-off value), male and female; * Expected survival \> 12 weeks; * ECOG score 0-1; * Bone marrow examination clearly diagnosed as B-cell acute lymphoblastic leukemia , CD19 or/and CD22 positive , and who met one of the following conditions: 1. Those who failed to achieve CR after at least 2 courses of standard chemotherapy or had early relapse after complete remission (\<12 months) or late relapse after complete remission (≥ 12 months) and failed to achieve CR after 1 course of standard chemotherapy; 2. For Ph+ ALL: in addition to receiving at least 2 courses of standard chemotherapy, at least two TKIs should be treated with no complete remission or relapse after complete remission; (Patients who cannot tolerate TKI therapy or have TKI treatment contraindications or have T315i mutation are excluded); 3. Those who relapse after stem cell transplantation are not affected by previous treatments; * The venous access required for collection can be established and mononuclear cell collection can be determined by the investigators; * Liver, kidney and cardiopulmonary functions meet the following requirements: 1. Serum creatinine≤1.5×ULN; 2. Left ventricular ejection fraction\>50%; 3. Baseline blood oxygen saturation\>96%; 4. Total bilirubin≤2×ULN; ALT and AST≤3×ULN (As judged by the investigator, the elevation of transaminase caused by the ALL disease itself, ALT and AST≤5×ULN); * Able to understand and sign the Informed Consent Document. Exclusion Criteria: Any one of the following conditions cannot be selected as a subject： * Graft-versus-host disease (GVHD), or need to use immunosuppressants after transplantation; * Patients with hyperleukocytosis (white blood cell count ≥50×10\^9/L) or whose disease progressed rapidly according to the investigator's judgment at the time of enrollment and cannot ensure the completion of a complete treatment cycle; * Malignant tumors other than acute lymphoblastic leukemia within 5 years prior to screening, in addition to adequately treated cervical carcinoma in situ, basal cell or squamous cell skin cancer, localized prostate cancer after radical resection, ductal carcinoma in situ after radical resection and thyroid cancer after radical resection ; * Subjects with positive HBsAg or HBcAb and peripheral blood HBV DNA titer detection higher than the lower limit of the research center can detect; HCV antibody positive and peripheral blood HCV RNA positive; HIV antibody positive; syphilis positive; * Any instability of systemic disease, including but not limited to unstable angina, cerebrovascular accident, or transient cerebral ischemic (within 6 months prior to screening), myocardial infarction (within 6 months prior to screening), congestive heart failure (New York heart association (NYHA) classification ≥ III), need drug therapy of severe arrhythmia, liver, kidney, or metabolic disease; * Active or uncontrollable infection requiring systemic therapy within 14 days prior to enrollment; * Pregnant or lactating woman, and female subject who plans to have a pregnancy within 1 year after cell transfusion, or male subject whose partner plans to have a pregnancy within 1 year after cell transfusion; * Received CAR-T treatment or other gene therapies before enrollment; * Patients with symptoms of central nervous system; * Subjects who are receiving systemic steroid treatment and requiring long-term systemic steroid treatment during the treatment as determined by the investigator before screening (except inhalation or topical use); * The investigators consider other conditions unsuitable for enrollment.