Assessment of the NIPE in Very Premature Infant Ventilated and Sedated in Neonatal Reanimation.

University Hospital, Lille50 enrolled

Overview

The Newborn Infant Parasympathetic Evaluation (NIPE) was developed as a method of analysis of the heart rate variability. The monitor gives a value between 0 (low value of the parasympathetic component) and 100 (high value of the parasympathetic component). So far, the measure of the heart failure variability by using the NIPE in infant born very premature ventilated and sedated in neonatal reanimation has not been realised and validated as an evaluation method of the pain and discomfort related to neonatal care.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Neonatal Pain Measurement Reanimation

Interventions

Pain measurement during care procedures in neonatal reanimationDEVICE

Eligibility

Sex: ALLMin age: 0 DaysMax age: 7 Days

Medical Language ↔ Plain English

Inclusion Criteria: * Infant born very premature before 34 weeks of amenorrhoea + 0 day * Age ≤ 7 days * Admitted in neonatal reanimation * Sedated, intubated, ventilated Exclusion Criteria: * High frequency oscillation ventilation * Heart rate non sinusal * Inotropes and atropine * Opposition from the guardian of parental authority * Difficulty of comprehension or communication making the parental information impossible

Outcomes

Primary Outcomes

Variation of the NIPE measures between before and during care.

Average of NIPE mesures 10 minutes before the begining of the care and 10 minutes after.

Time frame: From 10 minutes before the care to 10 minutes after the beginning of the care

Secondary Outcomes

Correlation between the variation of the NIPE measures and the variation of PIPP-R behavioural scale between each period

The average of NIPE mesures 10 minutes before care, 10 minutes after the begining and 10 minutes after the end of the care were collected. And the same for the PIPP-R behavioral scale mesures.

Time frame: From 10 minutes after the beginning of the care to 10 minutes after the end of the care

Correlation between the NIPEmin and the PIPP-R behavioural scale for each period

The lowest NIPE mesures during the 10 minutes before care, 10 minutes after the begining and 10 minutes after the end of the care were collected. And the same for the PIPP-R behavioral scale mesures.

Time frame: From 10 minutes before the care to 10 minutes after the care

The discriminant power of the NIPE to split the painful population and the non-painful population determined by a threshold at 6 on the PIPP-R scale

Study the discriminant power of the NIPE to split the painful population and the non-painful population determined by a threshold at 6 on the PIPP-R scale