Effects of Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation, Blood Pressure and Heart Rate Variability in Patients With Cerebral Small Vessel Disease

Inclusion Criteria: * 1\) Regardless of age, sex; * 2\) Patients are diagnosed with cerebral small vessel disease, and neuroimaging shows new subcortical lacunar infarction (in line with one of the following): ① MRI examination Diffusion-weighted imaging (DWI) phase shows high signal intensity \[Apparent Diffusion Coefficient (ADC) diffusion restriction\] lesions \< 20 mm diameter in subcortical, basal ganglia or brainstem , with or without corresponding clinical symptoms; ② With new clinical symptoms, MRI examination FLAIR sequence shows corresponding FLAIR high signal intensity lesions \[diameter \< 20 mm\]) in subcortical, basal ganglia or pons; * 3\) Remote ischemic conditioning can be started within 7 days from onset; * 4\) Willing to participate and sign the informed consent. Exclusion Criteria: * 1\) Vascular stenosis \> 50% by Transcranial Doppler (TCD); * 2\) Previous history of intracranial hemorrhage or major bleeding in other parts of the body; * 3\) Previous history of atrial fibrillation or myocardial infarction within 6 months; * 4\) Moyamoya disease or hereditary cerebral small vessel disease, such as mitochondrial encephalopathy, CADASIL or Fabry; * 5\) The patients who had clear non-vascular white matter lesions, such as multiple sclerosis, adult white matter dysplasia, metabolic encephalopathy; * 6\) Severe hepatic and renal diseases, cancer or other major diseases related to medical and surgical procedures; * 7\) The patients who had the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture or vascular injury in the upper limb; Acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc; * 8\) Significant coagulation abnormalities; * 9\) Pregnant or lactating women; * 10\) The patients with disturbance of consciousness or agitation who cannot cooperate to dynamic cerebral autoregulation monitoring or beat-to-beat blood pressure monitoring; * 11\) Previous remote ischemic conditioning therapy or similar treatment; * 12\) Unwilling to be followed up or treated for poor compliance; * 13\) He/She is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission; * 14\) Other conditions that the researchers think are not suitable for the group.