Study of the Safety and Pharmacokinetics of KSP-1007 Alone and Coadministered With Meropenem in Healthy Subjects

Inclusion Criteria: * Healthy male or female subjects 18 to 55 years of age, inclusive * Females that engage in heterosexual activity must agree to use a highly selective birth control (BC) method (\< 1% failure rate per year) throughout the study, or have a documented reproductive status of non-childbearing based on medical history, or is postmenopausal * Males that engage in heterosexual activity that has the risk of pregnancy must agree to use effective BC and agree to not donate sperm during the study and for at least 90 days after the last dose of the study medication * Body mass index (BMI) 2: 18 kg/m2 and :s 32 kg/m2 Exclusion Criteria: * History of Gilbert's Syndrome * History of severe allergic reactions to β-lactams or β-lactamase inhibitors or a history allergic reactions to multiple medications. * Pregnant female, determined by positive serum or urine human chorionic gonadotropin pregnancy test at Screening, or prior to dosing * Lactating female * Donation of plasma within 7 days prior to dosing. Donation or loss of blood (excluding volume drawn at Screening) of \> 499 mL within 56 days prior to Day 1 * Participation in a study with an investigational drug or device study with last dose of investigational drug within 30 days (90 days if the study involved a biologic, cellular, or vaccine product) or 5 half-lives, whichever is longer, before study treatment administration * Subjects with abnormal hepatic and/or renal function, that could interfere with the metabolism, and/or excretion of the study treatments * Abnormal blood pressure, either low (defined as \< 90 mmHg systolic and/ or \< 45 mmHg diastolic) or high (defined as \> 140 mmHg systolic and/ or \> 90 mmHg diastolic) at Screening * Positive serology for hepatitis B virus (HBV), hepatitis C virus (HCV), or HIV at Screening. Subjects who test positive for hepatitis B core antibody (HBcAb) or hepatitis B surface antigen (HBsAg) also will be ineligible. Evidence of prior HBV vaccination (positive hepatitis B surface antibody \[HBsAb)) is not exclusionary. * Subjects unable to abstain from alcohol for 48 hours prior to admission through to completion of the Follow-up visit