Carbon Dioxide（CO2）Fractional Laser Plus Photodynamic Therapy in Female Patients With Vulvar Lichen Sclerosus

Inclusion Criteria: 1. Age 18-60 (inclusive), female patients; 2. present typical clinical manifestations of of vulvar lichen sclerosus, confirmed by histopathological examination; 3. Volunteer to participate in this study and sign an informed consent form. Exclusion Criteria: 1. Severe organic diseases, such as severe heart, lung, liver, kidney insufficiency, coagulation dysfunction, etc.; 2. Suffer from autoimmune diseases, such as systemic lupus erythematosus, thyroid disease, etc.; 3. Suffer from photoallergic diseases, such as chronic photosensitivity dermatitis, plant solar dermatitis; 4. People with porphyria or porphyria allergy; 5. Suffer from psychiatric diseases, such as schizophrenia, etc.; 6. Those who are undergoing systemic treatment due to malignant tumor diseases, such as cervical cancer; 7. It is confirmed by laboratory pathogenic screening to have syphilis, HIV, and other sexually transmitted diseases or viral hepatitis; 8. Patients with current bacterial or fungal infections in the anus and genitals; 9. Women of childbearing age who have pregnancy plans, are pregnant, or are breastfeeding during the observation period of this study; 10. Patients who are systematically using glucocorticoids, immunosuppressants, and anticoagulants; 11. Use glucocorticoids for topical or local injection and calcineurin inhibitors for topical use within 4 weeks; 12. Those who are allergic to 5-aminolevulinic acid or its base, mometasone furoate or its base; 13. Other situations that the investigator considers inappropriate to participate in the clinical study.