Zofin to Treat COVID-19 Long Haulers

Inclusion Criteria: 1. Subjects age \> 18 years at the time of signing the informed consent form. 2. Male or female. 3. COVID-19 survivor and had documented SARS-CoV-2 positive (FDA EUA approved RT-PCR or equivalent tests such as FDA EUA approved Rapid Antigen Test which is performed at CLIA certified lab or the readout of the test reviewed and documented by a doctor). 4. Subject experiencing fatigue for over 6 weeks after their positive test result while currently being negative. 5. Subject has not fully recovered from COVID-19 for at least over 6 weeks despite a negative SARS-COV-02 test. 6. Subjects tested positive for anti-SARS-CoV-2 antibodies using FDA EUA approved test. 7. Subject is experiencing the following three symptoms for at least over 6 weeks either continually or intermittently with relapses not experienced pre-illness, that interferes with normal daily activities. Symptoms must be new symptoms i.e., subject didn't have symptoms, and had not sought medical treatment for the symptoms prior to COVID-19: * Extreme fatigue - feeling overtired with low energy and a strong desire to sleep but unable to have good sleep. * Body aches - muscle soreness or generalized achiness throughout the body. * Joint pain - pain in the joints due to inflammation not experienced before illness. 8. Chalder Fatigue Scale Bimodal Score ≥ 4 at the time of Screening. 9. Fatigue Severity Scale (FSS) ≥ 4 at the time of Screening. 10. Fatigue Assessment Scale Score (FAS) ≥ 10.5 at the time of Screening. 11. Beck Depression Inventory (BDI) score \<15 at the time of Screening (score of 15 is an exclusion). 12. Investigator(s) has access to medical documentation of previous COVID-19 treatments. 13. Ability of subject to understand and the willingness to sign a written informed consent document. 14. Subjects must be reasonably able to return for multiple follow-up visits. 15. Adequate venous access. 16. For Subjects of Child-Bearing Potential only, willingness to use FDA recommended birth control until 6 months post-treatment. The FDA approved and cleared methods for birth control are listed below: * Permanent sterilization * Long-acting reversible contraceptives (LARC) * Contraceptive injection * Short-acting hormonal methods * Barrier methods * Emergency contraception https://www.fda.gov/consumers/free-publications-women/birthcontrol 17. Any male subject must agree to use contraceptives and not donate sperm during the study. Exclusion Criteria: 1. Tested positive for SARS-CoV-2 infection at the time of screening (acute infection) which will involve a nasal swab sample or another FDA-approved test. 2. Subjects with a BDI ≥ 15 are excluded. 3. Subjects with homicidal or suicidal ideation are excluded. 4. Subjects with a diagnosis of depression upon entry into the study must have had at least 2-months of treatment (psychotherapy, antidepressive medication, or both) prior to enrollment, be stable on their current treatment regimen, and be followed by a medical provider who is actively treating and managing their depression throughout the study period. 5. Subjects who had recovered fully from COVID-19 and have a new onset of extreme fatigue, body aches, or joint pain that were due to other etiologies, not COVID-19 are excluded. 6. Subjects with serious co-morbidities are excluded. For example: * Liver enzymes are \>2X ULN; * eGFR is \<60 ml/min by the CKD- EPI equation; * Hb is \<11 mg/dL; * Platelet count is \<100K; * Uncontrolled arrhythmias; * BP systolic \<90 mmHg or \>160 mmHg; * Pulse is \<60 or \>100; * Respiratory rate is \<12 or \>25; * Abnormal ECG or any signs of active ischemic heart disease; * Heart failure of any degree (including NYHA classification Class 1- 4). 7. History of migraines prior to COVID-19 infection. 8. History of neuropathy prior to COVID-19 infection. 9. History of inflammatory and irritable bowel disease prior to COVID-19 infection. 10. History of depression and anxiety disorders prior to COVID-19 infection. 11. History of chronic fatigue syndrome, fibromyalgia, and arthritic disorders prior to COVID-19 infection. 12. Exhibiting signs of moderate or severe chronic respiratory disease (such as COPD, asthma, or pulmonary fibrosis) and history of these illnesses prior to COVID-19 infection. 13. Patient with rheumatologic disorders. 14. History of chronic liver disease or patient showing signs of clinical jaundice at the time of screening. 15. History of severe chronic kidney disease or requiring dialysis. 16. Showing signs of severe pneumonia, acute respiratory distress syndrome (ARDS), or respiratory failure needing mechanical ventilation. 17. Subjects with a history of bleeding disorders or currently on anticoagulation therapy that cannot be stopped prior to infusion which is not related to previous COVID-19 infection. 18. Oxygen-dependent on nasal canula greater than 2-L per minute. 19. Patient with pulse oxygen saturation (SpO2) of \<94% on room air. 20. Active or recently treated malignancies. 21. Any unstable condition of clinical significance, e.g., uncontrolled hypertension, unstable angina pectoris, worsening asthma. 22. Hydroxychloroquine, oral or parenteral corticosteroids, immunosuppressants, or immunomodulating agents within 7 days prior to the screening visit. 23. Albuterol as nebulizer for the off-label treatment of COVID-19 within 7 days prior to the screening visit. 24. Be a female who is pregnant, nursing, or of childbearing potential while not practicing effective contraceptive methods. Female subjects must undergo a blood pregnancy test at screening which will be within 72 hours of the IP infusion. 25. Subject has a body mass index (BMI) greater than 42 kg/m2 26. Subject has or had an active infection requiring systemic antibiotics within 12 weeks of enrollment in the study. 27. Inability to perform any of the assessments required for endpoint analysis. 28. Active listing (or expected future listing) for transplant of any organ. 29. Be a solid organ transplant recipient. This does not include prior cell based therapy (\>12 months prior to enrollment), bone, skin, ligament, tendon or corneal grafting. 30. Have a history of organ or cell transplant rejection. 31. History of drug abuse (illegal "street" drugs except marijuana, if it is legal to use in states where patient resides), or prescription medications not being used appropriately for a pre-existing medical condition or alcohol abuse (≥ 5 drinks/day for ˃ 3 months), or documented medical, occupational, or legal problems arising from the use of alcohol or drugs within the past 24 months. 32. Patients with untreated HIV infection. However, patients can be enrolled if have been treated for HIV and the test negative for HIV viral load but still test positive for antibodies.