Prevalence of Endolymphatic Hydrops With a Hitory of Congenital Cytomegalovirus Infection

Fondation Ophtalmologique Adolphe de Rothschild18 enrolled

Overview

The management of patients with a history of congenital CMV infection (whether symptomatic or asymptomatic at birth) is modeled on their usual management.

The management of patients with a history of congenital CMV infection (whether symptomatic or asymptomatic at birth) is modeled on their usual management. Patients benefit as part of the care: * A clinical cochleo-vestibular examination * Functional otoneurological explorations: audiogram, caloric tests, vHIT, otolithic evoked potentials * From an uninjected brain MRI Participation in this research entails the addition of an MRI sequence and an injection of contrast product (Gadovist®): \- 3D FLAIR MRI sequence dedicated to the exploration of the inner ear, lasting 6min30s, performed 4 hours after the initial injection of contrast product.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Endolymphatic Hydrops

Interventions

sequence MRI 3D FLAIRDEVICE

Participation in this research entails the addition of an MRI sequence and an injection of contrast product (Gadovist®): \- 3D FLAIR MRI sequence dedicated to the exploration of the inner ear, lasting 6min30s, performed 4 hours after the initial injection of contrast product

Eligibility

Sex: ALLMin age: 6 Months

Medical Language ↔ Plain English

Inclusion Criteria: * Patient over 6 months old * With a history of confirmed congenital CMV infection * Suffering from symptomatic cochleo-vestibular dysfunction (average hearing threshold\> 20dB in at least one ear and / or abnormal functioning of one or more sectors at the vestibular level) * For adult patients, having received informed information about the study and having signed a consent to participate in the study * For minor patients written consent of the two holders of the exercise of parental authority * Affiliate or beneficiary of a social security scheme Exclusion Criteria: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman * Contraindication to MRI (implanted electrical device, metallic foreign body, claustrophobia) * Patient with a proven allergy to gadolinium * Injection of gadolinium in the previous 7 days * Known impairment of renal function ((estimated GFR \<60 mL / min / 1.73 m²)

Locations (2)

Hôpital Fondation Adolphe de Rothschild

Paris, PARIS, France

Hôpital Robert Debre

Paris, France

Outcomes

Primary Outcomes

the prevalence of at least one endolymphatic hydrops in patients with a history of congenital CMV infection with symptomatic cochleovestibular dysfunction

Endolymphatic hydrops visualized with 3D FLAIR sequence in MRI

Time frame: 4 hours after the initial injection of gadolinium, at least for one of the two ears

Data from ClinicalTrials.gov

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