Pituitary Gland Stimulation for Cancer Pain Relief

Inclusion Criteria: * Adult patient * In palliative phase of metastatic disease, without options for further systemic treatment or radiotherapy * Inadequately controlled pain with standard care * Most prominent part of experienced pain is nociceptive * Karnofsky Performance Score ≥30 Exclusion Criteria: * Not fit for general anesthesia * Pregnancy * Unfavorable local anatomy for PGS, due to a disease process, or anatomical configuration * Clinical signs of posterior pituitary gland disfunction * Recent history of alcohol or drug abuse * Severe immunodeficiency * Need for anticoagulation therapy that cannot be abrogated for surgery * Need for subsequent MRI-imaging * Cognitive impairments prohibiting full understanding of study and ability to provide informed consent * Not able to adequately communicate in Dutch or English