High-fat Meal Challenge in Pediatrics

Dartmouth-Hitchcock Medical Center15 enrolled

Overview

The objective is to determine if how physical fitness, measured using a treadmill maximal oxidative capacity test, is associated with the capacity to metabolize a high-fat meal in pediatrics (ages 8-17 years). Ability to metabolize the meal will be assessed by profiling mitochondrial and extra-mitochondrial fatty acid metabolites. The investigators will test if fatty acid oxidation mediates the relationship between fitness and markers of metabolic health, such as insulin resistance.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Pediatric Obesity Insulin Resistance

Interventions

High-fat ChallengeDIETARY_SUPPLEMENT

The shake will be composed of a mixture of BOOST Glucose Control(R) (Nestlé Products) supplemented with palm oil. Each participant will consume a volume of liquid equivalent to 25% of their estimated daily caloric needs, calculated by the USDA Dietary Reference Intakes using a moderate activity factor.

Eligibility

Sex: ALLMin age: 8 YearsMax age: 17 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Children ages 8-17 years with a BMI-percentile ≥ 5th. Exclusion Criteria: * Previous diagnosis of type 1 or 2 diabetes. * Use of concurrent medications known to affect glucose metabolism (metformin, oral steroids, sulfonylureas, insulin). * Evidence of inherited disorders of lipid metabolism. * Inability to participant in the maximal aerobic capacity test on the treadmill. * Allergies to palm oils or protein types within high-fat challenge, such as lactose and soy. * Individuals who cannot speak and/or write in English.

Locations (1)

Dartmouth-Health

Lebanon, New Hampshire, United States

Outcomes

Primary Outcomes

Palatability of the High Fat Agent.

Determine the number of participants that complete at least 75% of the shake (by weight).

Time frame: 10 minutes

Secondary Outcomes

BMI Percentile

BMI percentile calculated for each participant. Average and standard deviations were reported.

Time frame: At baseline

Medium Chain Acylcarnitine Concentration

Medium chain acylcarnitines profiled in the plasma include acylcarnitine 6:0, 8:0, 10:0, 10:1, 12:0, and 12:1. Medium chain acylcarntine concentration was averaged in each participant. Average and standard deviations were reported.

Time frame: 60 and 180 minutes post consumption of high fat shake

Fold Change of Medium Chain Acylcarnitine at 60 and 180 Minutes.

Time frame: 60 and 180 minutes post consumption of high fat shake

Data from ClinicalTrials.gov

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