Immunity and Nasal Fungal Colonization

Taichung Veterans General Hospital58 enrolled

Overview

Fungal colonization causes opportunistic infection that may manifest when the host's immune status deteriorates. The purpose of this study was to determine the prevalence of fungal colonization in immunocompromised subjects compared to healthy controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Colonization, Asymptomatic

Interventions

nasal irrigationOTHER

regular saline nasal rinse

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Immunocompromised subjects included those who had known risk factors for fungal infection, including malignant diseases, diabetes, autoimmune disorders, renal or hepatic insufficiency, organ transplantation, or use of immunosuppressants * Healthy volunteers had neither sinonasal symptoms nor nasal endoscopic inflammation. Exclusion Criteria: * Patients were excluded if they were under 20 years old, were receiving antifungal medication, or were pregnant.

Locations (1)

Department of Otolaryngology, Taichung Veterans General Hospital

Taichang, Taiwan

Outcomes

Primary Outcomes

nasal lavage pooled fungal microbiota

Time frame: 1 month

Secondary Outcomes

nasal lavage aspergillus qPCR

Time frame: 1 month

Data from ClinicalTrials.gov

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