Evaluation of the Effect of Pomegranate Peel Added Bread on Blood Sugar, Fats, and the Body's Defense Response

Toros University30 enrolled

Overview

The aim of this study is to evaluate the effects of the consumption of bread produced with the addition of pomegranate peels, which has a high antioxidant content, on blood glucose and lipid parameters, and some oxidant-antioxidant enzymes and lipid peroxidation in individuals with type 2 diabetes.

Between 01.02.2022 and 30.05.2022 with Specialist Dr. Emel SENOL's approval, by Specialist Dr. Akkız Zuhal ÖZTAŞ The study will be conducted with 30 volunteers who present to the City Hospital Internal Medicine Polyclinic in Mersin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Type 2 Diabetes

Interventions

Pomegranate PeelDIETARY_SUPPLEMENT

Standard bread and test breads (with added pomegranate peel) to be used in the study will be produced by Asst. Prof. Özlem ÖZPAK AKKUŞ in the Nutrition Principles Laboratory of Toros University. For standard bread, 900 ml of water, 42 fresh yeast, 12 g of salt and 12 g of sunflower oil will be added to 1000 g of sifted whole wheat flour and the prepared bread mixture will be divided into 40 equal parts. To make bread with pomegranate peel added, 1000 g of sifted whole wheat flour, 20 g of pomegranate peel powder, 914 ml of water, 42 g of fresh yeast, 12 g of salt and 12 g of sunflower oil will be added and the prepared bread mixture is divided into 40 equal parts with 500 mg of pomegranate peel powder in each piece).

Eligibility

Sex: ALLMin age: 19 YearsMax age: 64 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Being diagnosed with type 2 diabetes for at least 5 years, * Using only oral antidiabetic * With a Body Mass Index (BMI) value ≥ 25.0 kg/m2, * Signing the Informed Voluntary Consent Form, * Being in an age range of 19-64 years. Exclusion Criteria: * Having kidney, liver, and inflammatory diseases, * Being on insulin therapy, * Using prescription drugs and/or fiber supplements, * Taking vitamin and mineral supplements, * Being pregnant/lactating, * Consuming excessive alcohol (\>2 drinks/day), * Being in the menstrual period, * Receiving gluten enteropathy, * Having allergy against pomegranate. * In addition, individuals with Covid-19-related condition during the study process will be excluded from the study.

Locations (1)

Özlem ÖZPAK AKKUŞ

Mersin, Yenişehir, Turkey (Türkiye)

Outcomes

Primary Outcomes

Biochemical Blood Parameters

Examination of between group differences regarding lipid profile

Time frame: First day at the beginning of the study

Biochemical Blood Parameters

Examination of between group differences regarding HbA1c

Time frame: First day at the beginning of the study

Biochemical Blood Parameters

Examination of between group differences regarding insulin

Time frame: First day at the beginning of the study

Biochemical Blood Parameters

Examination of between group differences regarding TAC

Time frame: First day at the beginning of the study

Biochemical Blood Parameters

Examination of between group differences regarding TBARS

Time frame: First day at the beginning of the study

Anthropometric Measurements - Weight

Examination of between group differences regarding weight in kilogram

Time frame: First day at the beginning of the study

Anthropometric Measurements - Height

Examination of between group differences regarding height in meter

Time frame: First day at the beginning of the study

Anthropometric Measurements - Body Mass Index

Examination of between group differences regarding body mass index (BMI = weight in kilogram / height in meter 2)

Time frame: First day at the beginning of the study

Data from ClinicalTrials.gov

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