Root Resorption Accompanied Clear Aligners and Fixed Orthodontic Appliance

Inclusion Criteria: * Healthy systemic condition/no systemic illness, as reported by patients. * No use any form of anti - inflammatory drugs the at beginning of study. * Good oral hygiene. * Cooperative and motivated. * In the permanent dentition with all teeth present ( except third molars). * Minimum to moderate anterior crowding. * No previous orthodontic treatment. Exclusion Criteria: * Previous upper removable orthodontic treatment. * Patients who required surgery to correct skeletal discrepancies. * Patients with hyperdontia, hypodontia, or syndromic diseases (e.g. cleft lip and palate). * Uncooperative patients. * Patients with poor oral hygiene.