The type of cooking oil used is a crucial factor influencing dietary quality. The purpose of this study is to investigate the effects of olive oil and MLCT oil intervention on glucose and lipid homeostasis in patients with MetS.
We conducted a 6-month RCT to evaluate the effects of olive oil and MLCT as cooking oils on glucose and lipid homeostasis in patients with MetS; investigate the changes in lipoprotein subfractions and metabolites using NMR spectroscopy, alongside gut microbiota alterations, to elucidate potential mechanisms; and identify baseline variables associated with the anti-obesity effects of olive oil and MLCT.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
240
Olive oil, 25-30g/d by day for 6 month
MLCT oil, 25-30g/d by day for 6 month
Lanxi Hospital of Traditional Chinese Medicine
Jinhua, Zhejiang, China
Change in body weight from baseline
The investigators will measure body weight of participants before and after treatment.
Time frame: 6 month
Change in triglycerides from baseline
The investigators will measure triglyceride levels in blood samples before and after treatment.
Time frame: 6 month
Change in Body fat distribution and muscle conten from baseline
The whole body of the patient was scanned and analyzed by a DXA (Prodigy Primo, Dalex-Ohmeda, Inc., USA) to measure the total and regional body fat mass (FM) and lean mass.
Time frame: 6 month
Change in waist circumference from baseline
The investigators will measure waist circumference of participants before and after treatment.
Time frame: 6 month
Change in MetS indicators from baseline
The investigators will measure TC, LDL-C, HDL-C, and glucose levels in blood samples and blood pressure before and after treatment.
Time frame: 6 month
Change in gut microbiota from baseline
The investigators will collect faeces sample from every participants and 16S rDNA sequencing will be used to analyze the composition of gut microbiota.
Time frame: 6 month
Change in blood metabolome
The investigators will collect blood samples from every participant and the high-throughput NMR metabolomics platform will be used to analyze the blood metabolomics profile.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 6 month