Study to Assess Signature Cord Product in Patients With Symptomatic OA of the Knee

Inclusion Criteria: * Diagnosis of osteoarthritis of the knee based on clinical and radiographic findings * Kellgren-Lawrence Grades 2-3 * Average pain score, on a 100-point numerical rating scale (VAS), over the past 7 days of \> 40 and \< 90 in the index knee and \< 40 in the contralateral knee * Body mass index \< 35 kg/m² * Ability to comply with the requirements of the study * Ability to understand and provide written informed consent * Not suspecting or expecting to be pregnant during the study period * All participants of reproductive age/capacity to confirm the use of adequate contraception during the study period Exclusion Criteria: * Prior therapeutic radiation to the index knee * Use of any pain medication or therapy less (anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDS) oral and topical, topical CBD, and narcotics) than 15 days prior to test product administration that has not or will not have had a stable dosage, frequency, or intensity for at least 3 months prior to test agent administration. Use of oral NSAIDs at a stable dose at least 3 months prior to test agent administration must be continued through the study period. * Intra-articular treatment with corticosteroids, regenerative medicines (e.g., plasma, stem cell, placental products), or systemic steroid use within 3 months prior to screening * Intra-articular treatment with hyaluronic acid within 6 months prior to screening * Surgical intervention on the index knee \< 12 months, or arthroscopy \< 3 months prior to screening * Non-ambulatory status * Past or current diagnosis of fibromyalgia or inflammatory arthritis, gout, rheumatoid arthritis, lupus arthropathy, psoriatic arthritis, avascular necrosis, severe bone deformity, active infection of the index knee joint or at the site of injection, pes anserine bursitis, neurogenic or vascular claudication, or uncontrolled diabetes mellitus (HbA1C\>8%) * Diagnosis of arthritis due to traumatic injury or meniscal tear in the index knee within 2 years of screening * Moderate or large knee effusion in the index knee at screening and at test agent administration that requires drainage for diagnostic purposes or symptomatic relief * Clinically significant, ongoing illness or medical condition that in the opinion of the investigator constitutes a safety risk for participation in the study or that could interfere with achieving the study objectives, conduct or evaluation * Females who are pregnant or lactating * Regular use of anticoagulants (daily use of aspirin ≦ 325 mg is acceptable) * Active alcohol or substance abuse or any other reason that makes it unlikely that the subject will comply with study procedures * Subjects with a psychiatric illness or condition, which, in the opinion of the investigation, would interfere with the conduct of the study or the interpretation of study results. Subjects with stable anxiety and depression defined as being on stable doses of antidepressant and anxiety drugs for the last 6 months and for which no dose changes are expected during the study can be included. * Clinically significant medical, surgical, psychiatric, or laboratory abnormality that, in the judgment of the investigator, is likely to adversely affect the subject's risk-benefit or interfere with study compliance or assessment of safety or efficacy. * Known allergy to local anesthetics or components of the study drug. * Subjects with autoimmune disease or a known history of having Acquired Immunodeficiency Syndromes (AIDS) or Human Immunodeficiency Virus (HIV).