To investigate the safety and efficacy of preoperative IMRT and concurrent Apatinib for primary truncal or extremity soft tissue sarcoma; To investigate the Quality of life and extremity function post-combination treatment; To study the mechanism of radio-sensitizing effects of Apatinib for primary truncal or extremity soft tissue sarcoma; To assess the relationship between the MRI imaging, pathological findings and local control.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Apatinib Mesylate 500mg QD, begin from 2 weeks prior to IMRT, to 1 month after end of IMRT
Radiotherapy Department of Cancer Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
Rate of Major wound complications within 4 months post-surgery
Time frame: 4-months post-surgery
Acute and late toxicities
Number of participants with treatment-related adverse events as assessed by CTCAE v5.0
Time frame: acute toxicities were evaluated during and 3 months after IMRT, late toxicities were evaluted after 6 months
Patient-reported Quality of Life assessed by EORTC-QLQ-C30 questionnaire
Evaluate the quality of life by patient-reported EORTC-QLQ-C30 questionnaire at different time points
Time frame: From date of enrollment to 2 years after surgery, specifically at pre-IMRT, end of IMRT, 1 months post-IMRT, and every 3 to 6 months during follow-up up to 2 years post-surgery
Extremity function scores
Evaluate the extremity function by MSTS (Musculoskeletal Tumor Rating Scale) and TESS (Toronto Extremity Salvage Score) forms at different time points
Time frame: From date of enrollment to 2 years after surgery, specifically at pre-IMRT, end of IMRT, 1 months post-IMRT, and every 3 to 6 months during follow-up up to 2 years post-surgery
Pathological remission rate
Evaluate the tumor remission rate microscopically 2 weeks after operation
Time frame: 2 weeks after operation
Local control
Time frame: 2-year
Overall survival
Time frame: 2-year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.