Prediction of Recurrence and Complications of Nephrolithiasis Using a Precision Medicine Approach

Centre Hospitalier Universitaire, Amiens2,000 enrolled

Overview

Nephrolithiasis is a disease caused by the formation of kidney stones in the urinary tract which can then partially or completely obstruct the latter causing an extremely sharp pain called renal colic. In industrialized countries, it affects 10 to 20% of the population, and is the most common kidney disease.The primary objective of this study is to identify the clinical, biological, genetic, molecular and environmental determinants predictive of recurrence of renal lithiasis. The study follow-up visit schedule corresponds to the visits usually scheduled as part of patient care: 1 year from the inclusion visit (A1), 3 years (A3) then 5 years (A5). Samples for research (additional volume of blood, urine) will be taken by a registered nurse along with the routine check-up samples.Samples intended for research will be sent by staff to the Biobanque de Picardie (CHU Amiens-Picardie) for processing and conservation.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

2,000

Conditions

Kidney Stone Nephrolithiasis

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults (≥18 years old), male or female , * Persons able to understand and object to the information provided (at the discretion of the investigator) * Patient affiliated to social security * Patient agreeing to sign the informed consent form * patient having presented at least one renal colic attack before inclusion Exclusion Criteria: * Pregnant or breastfeeding woman. * Persons deprived of liberty, * Adults under legal protection guardianship, or curators or unable to express their consent. * Patient refusing to participate in the study * Patient in an emergency situation

Outcomes

Primary Outcomes

Number of patients with nephrolithiasis recurrence within 5 years of follow-up

Time frame: at 5 years

Secondary Outcomes

Occurrence of high blood pressure patients

Time frame: at 1 year

Occurrence of high blood pressure patients

Time frame: at 3 years

Occurrence of high blood pressure patients

Time frame: at 5 years

Occurrence of patients with diabetes

Time frame: at 1 year

Occurrence of patients with diabetes

Time frame: at 3 year

Occurrence of patients with diabetes

Time frame: at 5 year

Occurrence of patients with osteopenia

Occurrence of patients with osteopenia during monitoring of bone mineral density with DXA

Time frame: at 1 year

Occurrence of patients with osteopenia

Occurrence of patients with osteopenia during monitoring of bone mineral density with DXA

Time frame: at 3 year

Occurrence of patients with osteopenia

Occurrence of patients with osteopenia during monitoring of bone mineral density with DXA

Time frame: at 5 year

Occurrence of patients with a deterioration in renal function

Occurrence of patients with a deterioration in renal function during follow-up

Time frame: at 1 year

Occurrence of patients with a deterioration in renal function

Occurrence of patients with a deterioration in renal function during follow-up

Time frame: at 3 year

Occurrence of patients with a deterioration in renal function

Occurrence of patients with a deterioration in renal function during follow-up

Time frame: at 5 year

Prediction of Recurrence and Complications of Nephrolithiasis Using a Precision Medicine Approach

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts