The hypothesis of this study is that Magnesium sulfate pretreatment (50mg/kg) will reduce the incidence of cough and chest wall rigidity caused by remifentanil administration. The purpose of this study was to investigate the effect of magnesium sulfate administered before induction of anesthesia on thoracic stiffness and cough response caused by opioid analgesics administered for general anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
78
magnesium sulphate 50mg/kg (loading dose for 10 minutes), 15mg/kg/hr (continuous infusion)
normal saline 100ml (loading dose for 10 minutes), 15mg/kg/hr (continuous infusion)
remifentanil induced cough
To evaluate whether coughing occurs during anesthesia induction from the start of remifentanil infusion to the completion of laryngeal mask insertion.
Time frame: from preoperative 20 minutes to induction of anesthesia
severity of cough
mild: 1-2, moderate: 3-4, severe: ≥ 5
Time frame: from preoperative 20 minutes to induction of anesthesia
laryngeal mask airway (LMA) insertion compliance
Assess the number of trials prior to successful laryngeal mask insertion and the need for administration of a neuromuscular blocker.
Time frame: from preoperative 20 minutes to induction of anesthesia
lung compliance
Poor compliance of mechanical ventilation is defined as a difference between the set tidal volume and the actual tidal volume value applied to the patient by 100ml or more.
Time frame: from induction of anesthesia to finish of surgery
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