Volume Increase Versus Supplemental 4% Articaine Buccal Infiltration on Mepivacaine Inferior Alveolar Nerve Block Success

Cairo University75 enrolled

Overview

To assess the anesthetic success of inferior alveolar nerve block (IANB), intraoperative pain intensity and need for supplemental anesthesia on administration of 1.8ml or 3.6ml 2% mepivacaine IANB, or 1.8ml 2% mepivacaine IANB plus 1.8ml 4% articaine buccal infiltration (BI) in mandibular molars with symptomatic irreversible pulpitis.

Patients with moderate-to-severe preoperative pain related to mandibular molars with symptomatic irreversible pulpitis will be included. Patients receive 1.8 ml, 3.6 ml 2% mepivacaine IANB, or 1.8ml 2% mepivacaine IANB plus 1.8ml 4% articaine BI. Anesthetic success of inferior alveolar nerve block, intraoperative pain intensity and need for supplemental anesthesia will be assessed during treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Symptomatic Irreversible Pulpitis

Interventions

1.8 ml mepivacaine hydrochlorideDRUG

1.8 ml mepivacaine IANB

3.6 ml mepivacaine hydrochlorideDRUG

3.6 ml mepivacaine IANB

1.8 ml mepivacaine hydrochloride IANB plus 1.8 ml articaine hydrochloride BIDRUG

1.8 ml mepivacaine IANB plus 1.8 ml articaine BI

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients in good health (ASA Class I, II). 2. Age between 18-60 years old. 3. Males or females. 4. Mandibular molar teeth diagnosed with symptomatic irreversible pulpitis. 5. Patients who can understand NRS scale and sign the informed consent. Exclusion Criteria: 1. Patients who had used any type of analgesic medication during the preceding 8 hours before the treatment. 2. Pregnant or nursing females. 3. Patients with a contraindication for the use of mepivacaine, articaine or any used drug or material.

Outcomes

Primary Outcomes

Anesthetic success

Will be recorded by 11-point numerical rating scale (NRS) consisting of numbers from 0 through 10. 0: reading represents "no pain" 1-3 : readings represent "mild pain" 4-6 : readings represent "moderate pain" 7-10 : readings represent "severe pain". Success will be defined as no to mild pain.

Time frame: During the treatment

Secondary Outcomes

Intraoperative pain

Time frame: During the treatment

Need for supplemental anesthesia

Whether the patient requires supplemental anesthesia or not

Time frame: During the treatment

Central Contacts

Reham Anwar Sleem

CONTACT

00201014110666 reham.anwar@dentistry.cu.edu.eg

Data from ClinicalTrials.gov

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