Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and Kidney Uptake

Université de Sherbrooke10 enrolled

Overview

The objective of this study is to make a comparison between 11C-acetate and 11C-Acetoacetate heart and kidney metabolism

Healthy people will have two positron emission tomography scan to perform. One, with a 11C-Acetate Tracer and the other with 11C-Acetoacetate. The results will allow to determine if both tracers are used in a similar way but the organs and see if the investigators can use the already validated analyse method for acetate to make acetoacetate analysis

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Ketoses, Metabolic

Interventions

Observational heart and kidney on siemens TEP scanRADIATION

Same as arm description

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Aged between 18 and 55 * BMI between 18,5 and 28 * Healthy * Normal value for blood pressure Exclusion Criteria: * Taking drugs that could influence metabolism * Diabetes or prediabetes * Pregnancy or lactation * Participation in a intensive sport program * Being on a ketogenic diet * Any clinical abnomally in prescreen blood sample

Locations (1)

Research Center on Aging

Sherbrooke, Quebec, Canada

Outcomes

Primary Outcomes

Mean in left ventricule myocradial blood flow

Heart acetate metabolism measured by TEP scan

Time frame: 30 minutes

Mean in left ventricule myocardial blood flow

Heart acetoacetate metabolism measured by TEP scan

Time frame: 30 minutes

Mean in Kidney acetate uptake

Kidney acetate uptake measured by TEP scan

Time frame: 30 minutes

Mean in Kidney acetoacetate uptake

Kidney acetoacetate uptake measured by TEP scan.

Time frame: 30 minutes

Data from ClinicalTrials.gov

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