Clinical Outcomes of Patients With Deferred Revascularization Based on FFR and iFR Negative Coronary Artery Lesions.

Aga Khan University Hospital, Pakistan345 enrolled

Overview

The objective is to assess long-term clinical outcomes of patients in whom intervention of coronary lesions was deferred due to negative fractional flow reserve (FFR) and negative Instantaneous wave-free ratio (iFR) in a real-world patient population and to identify factors associated with deferred target lesion failure.

Fractional flow Reserve (FFR) evaluates functional significance of stenosis in intermediate coronary lesions. Instantaneous wave-free ratio (iFR) is considered noninferior to FFR and does not require adenosine administration. This study was done to assess long-term clinical outcomes and factors associated with target vessel revascularization (TVR) in patients with deferred revascularization based on negative FFR and iFR. Retrospective analysis of medical records of 345 patients with deferred revascularization at a tertiary care hospital , from January 2012 to January 2020 will be done.

Study Type

OBSERVATIONAL

Enrollment

345

Conditions

Coronary Artery Disease

Interventions

Fractional flow reserve, instantaneous wave-free RatioDIAGNOSTIC_TEST

Clinical outcomes observed for patients with moderate coronary lesions in whom coronary revascularization was deferred due to a negative physiologic study.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who had intermediate to severe coronary lesions on coronary angiogram. * Patients who had negative FFR \>0.80 or iFR \>0.89 and did not undergo immediate or planned revascularization on basis of negative physiologic assessment. Exclusion Criteria: * Patients younger than 18 years of age or those having positive FFR/iFR values irrespective of revascularization status were excluded. * Similarly, those who were lost to follow up and could not be traced via telephonic or were also excluded.

Locations (1)

Aga Khan University Hospital

Karachi, Sindh, Pakistan

Outcomes

Primary Outcomes

Cardiac death

Number of participants who died due to sudden cardiac arrest, sudden death due to acute MI and death due to heart failure or cardiogenic shock

Time frame: 29 months

Non-fatal myocardial infarction

Number of patients suffering from Myocardial infarction but did not die.

Time frame: 29 months

Target vessel revascularization.

Repeat PCI or bypass graft placement for a stenosis in another part of the vessel treated at the index PCI

Time frame: 29 months

Data from ClinicalTrials.gov

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