Exercise Training in Patients With Pulmonary Arterial Hypertension

Saglik Bilimleri Universitesi32 enrolled

Overview

In this study, the effects of kettlebell exercise training on functional capacity, dyspnea and activities of daily living in patients diagnosed with Pulmonary Arterial Hypertension (PAH) will be investigated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pulmonary Arterial Hypertension

Interventions

Kettlebell ExerciseOTHER

The exercise training plan for this group consists of 4 stages. Each stage lasts 2 weeks and consist of 5 kettlebell (KB) exercises. These exercises will continue from basic (single movement training) to advanced (comprehensive movement training) and is geared towards functional training. Participants will perform 2 sets of 12 repetitions of each exercise. Each training session is planned to last 45 minutes. The following exercises will be used in KB training: biceps curl, triceps extension, kettlebell swing (two-handed), kettlebell dead lift, kettlebell goblet squat, suitcase carry, waiter carry, bottoms up carry, farmer's walk, overhead carry, lunge, kettlebell row.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with pulmonary arterial hypertension (PAH) by a specialist physician in accordance with the 2015 guideline for the treatment and diagnosis of pulmonary hypertension of the European Heart and Respiratory Societies (ERS/ESC), * Patients with stable pharmacological treatment, * Patients clinically stable at least last three months. Exclusion Criteria: * Presence of orthopedic or neurological problems that will affect functional tests and muscle strength measurement, * Recent surgical procedures, * Recent syncope, * Pregnancy, * Presence of severe left heart failure, * Presence of severe ischemic heart disease, * Hypertensive patients, * Patients who have problems in communicating.

Locations (1)

Istanbul University - Cerrahpasa, Institute of Cardiology

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Task related oxygen uptake

Cardiopulmonary data will be evaluated with mobile cardiopulmonary exercise test during daily activities. Participants will perform the following activities with mobile cardiopulmonary exercise test (CPET): putting on socks on both feet (sitting on a chair), putting on both shoes (sitting on a chair), putting on a coat (while standing), lifting material (placing 6 jars -each 400 gram- at chest-level height), sweeping the floor for 4 minutes, washing dishes for 4 minutes, go up and down stairs - 1 floor. There will be a 5 minute rest between all activities.

Time frame: 8 weeks

Functional capacity

The 6-minute walk test will be performed.

Time frame: 8 weeks

Peripheral muscle strength

Isometric muscle strength will be measured with a handheld dynamometer for elbow flexion, knee extension, knee flexion, shoulder flexion, shoulder abduction, hip flexion and m.serratus anterior.

Time frame: 8 weeks

Handgrip strength

Hand grip strength will be measured with a digital hand dynamometer.

Time frame: 8 weeks

Secondary Outcomes

Activity status

This outcome will be assessed with the Duke Activity Status Index. As a result of scoring, a total score ranging from 0 to 58.2 is obtained. Higher scores indicate higher functional capacity.

Time frame: 8 weeks

Health-related quality of life

This outcome will be assessed with the emPHasis-10. emPHasis-10 consists of 10 items and results in a score out of 50, where a higher score represents a higher symptom burden.

Time frame: 8 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.