Sacubitril/Valsartan for CKD5 Stage Dialysis Patients

Inclusion Criteria: * CKD stage 5, starting regular hemodialysis or peritoneal dialysis for more than 1 month. * NT-proBNP ≥2000pg/ml. * hypertension * Voluntary informed consent. Exclusion Criteria: * Unable to tolerate ACEI/ARB class antihypertensive drugs; * History of symptomatic hypotension/systolic blood pressure \<100mmHg at screening; * Potassium \>6.0mmol/L; * History of angioedema; * Abnormal liver function such as ALT and/or AST \>=3 times normal upper limit (ULN), total bilirubin \>= 2 times ULN; * Moderate to severe anemia (hemoglobin \<80g/L); * Cardiac surgery/intervention/cardiac resynchronization therapy has been performed in the past 3 months or is planned in the next 12 months; * Newly found malignant tumor (within 3 years), or undergoing radiotherapy/chemotherapy; * Pregnant and lactating women, or those of childbearing age who are unable to guarantee effective contraception; * New and serious life-threatening infections; * Active infectious diseases such as active tuberculosis, active viral hepatitis and HIV infection; * Persons suffering from mental disorders and taking psychotropic drugs; * Patients with life expectancy less than 12 months; * The doctor assessed that the patient was not easy to follow up or had poor compliance and was not suitable for enrollment; * Patients who do not want to sign informed consent.