The components of metabolic syndrome (MetS), particularly obesity and dyslipidemia, are linked to peripheral neuropathy (PN) among patients with diabetes or even without diabetes. Several studies revealed that complementary and herbal medicine could provide a potential for PN management and MetS components. Thus, designing clinical trials with interventions combinations to achieve a considerable improvement is highly recommended. Hesperidin and diosmin, citrus-derived flavonoids, have been reported to possess anti-hyperlipidemic, anti-inflammatory, analgesic, antioxidant, antidiabetic, and anti-hypertensive effect with high tolerability and safety profile
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
129
patients were allocated to receive either hesperidin, diosmin, or combination of both and the fourth group was assigned as a control group without intervention
University
Al Fayyum, Egypt
metabolic syndrome components
Waist circumference, (cm)
Time frame: 12 weeks
metabolic syndrome components
FBG, mg/dl
Time frame: 12 weeks
metabolic syndrome components
LDL, mg/dl
Time frame: 12 weeks
metabolic syndrome components
HDL
Time frame: 12 weeks
metabolic syndrome components
TGs, mg/dl
Time frame: 12 weeks
MNSI score for neuropathy
neuropathy improvement if MNSI score decreased
Time frame: 12 weeks
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