This study will evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 in combination with a multiple myeloma (MM)-targeting monoclonal antibody capable of inducing antibody-dependent cellular toxicity (ADCC) in participants with relapsed or refractory (R/R) MM who have received a minimum of three prior treatments, including at least one immunomodulatory drug (IMiD), one proteasome inhibitor (PI), and one anti-CD38 monoclonal antibody.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
18
XmAb24306 will be given via intravenous (IV) infusion
Participants will receive daratumumab via subcutaneous (SC) injection every week for Cycles 1-4, every 2 weeks for Cycles 5-12, and every 4 weeks thereafter (cycle length = 2 weeks for Cycles 1-12 and 4 weeks thereafter)
Royal Adelaide Hospital
Adelaide, South Australia, Australia
Alfred Hospital
Melbourne, Victoria, Australia
Odense Universitetshospital
Odense C, Region Syddanmark, Denmark
Sygehus Lillebælt, Vejle
Vejle, Region Syddanmark, Denmark
Percentage of participants with adverse events (AEs)
Time frame: Up to approximately 3 years
Serum concentration of XmAb24306
Time frame: Baseline to approximately 3 years
Objective response rate (ORR)
Time frame: Baseline to approximately 3 years
Prevalence of XmAb24306 anti-drug antibodies (ADAs)
Time frame: Baseline to approximately 3 years
Incidence of XmAb24306 ADAs
Time frame: Baseline to approximately 3 years
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Oslo Universitetssykehus HF
Oslo, Norway
Hospital Universitario Germans Trias i Pujol
Badalona, Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain