Characterization of Retinal Microvascular and FAZ Changes in Ischemic Stroke and Its Different Types

Peking University Third Hospital100 enrolled

Overview

The study aimed to access the microvascular changes in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in patients with ischemic stroke and its different types using optical coherence tomography angiography.

Investigators used OCTA to quantitatively access the retinal microvasculature of SCP and DCP, aiming to detect the geometry changes of retinal microvasculature and FAZ in ischemic stroke patients and its different types.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Ischemic Stroke

Interventions

Optical Coherence Tomography AngiographyDEVICE

Optical coherence tomography angiography (OCTA) is a novel non-invasive, non-dye and high-resolution imaging technique, allowing real-time quantitative evaluation of retinal vasculature and the structure of foveal avascular zone (FAZ).

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Patients who were diagnosed with ischemic stroke by MRI were scheduled for an OCTA examination. The diagnosis of ischemic stroke was obtained from previous diagnostic reports or electronic medical records, according to the diagnostic criteria from the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Exclusion Criteria: 1\) Retinal diseases or diseases affecting vessel structure in fundus photography, including age-related maculopathy; diabetic retinopathy, central serous chorioretinopathy, retinal pigment epithelial detachment and glaucoma); poor cooperation in ophthalmic examinations; high refractive error (\>+6.00 D or \<-6.00 D Spherical Equivalent); low-quality OCTA images (signal strength index \< 6/10). Inclusion criteria for healthy controls were no history of ischemic stroke or other neurological and ocular diseases.

Locations (1)

Peking University Third Hospital

Beijing, China

RECRUITING

Outcomes

Primary Outcomes

Vascular Area Density(VAD)

The total length in millimeters of perfused retinal microvasculature per unit area in square millimeters in the annular region of analyzed area