Placental Perfusion in the Entire Placenta and With Sonobiopsy by Ultrasound

Szeged University150 enrolled

Overview

In this study is tested the validity of placental vascular indices obtained from placenta ultrasonographic sphere biopsy and entire placenta investigation.

Although, to this date, there have been a number of human placental studies that concerned the evaluation of placental 3 dimensional power Doppler vascularization with the use of VOCAL technique, but there was no one in which placental vasculature has been compared between the sonobiopsy and whole placental volume.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

150

Conditions

Placenta Diseases

Interventions

3 dimensional ultrasound investigationDIAGNOSTIC_TEST

Images that contributed to the determination of placental volume and 3-DPD indices were obtained at the time of visit. All 3-D scans ultrasound measurements were performed by a Voluson 730 Expert ultrasound machine equipped with a multifrequency probe (2-5 MHz) to acquire images. Each sample was examined using 3-D rendering mode, in which the colour and gray value information was processed and combined to supply 3-D image. For laterally located placentas, the investigator positioned the transducer on a slight lateral inclination to obtain proper images. Power Doppler window was placed over the placenta to map the vascular tree from basal to chorionic plates. The 3-D static volume box was placed over the entire placenta volume. The sweep angle was set at maximum 70°. Each image was recovered from the disk in succession for processing. During gestation, the investigator recorded one sample from each patient.

2 dimensional ultrasound investigationDIAGNOSTIC_TEST

The two-dimensional (2-D) transabdominal conventional study provided data about fetal position, biometry, body movements and fetal heart rate as well as placental localization. The factorial default setting 'Obstetrics' was applied in 2-D mode.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Exclusion criteria: * multiple pregnancy, * abnormal (\> 3mm) nuchal translucency from 11+0 to 13+6 weeks of gestation, * the fetal or neonatal structural or chromosomal anomaly, * inadequate localization of the placenta (placenta praevia), * self-reported drugs, alcohol, caffeine or nicotine abuse, * exposed to circulatory medication (oxerutins, calcium dobesilate) * or not signing the consent form. * If the mother suffer from er systemic disease (e.g. diabetes, autoimmune disease, vasculitis, haemophilia, thrombophilia, HIV infection, etc) Inclusion clriteria: * single pregnancy * healthy pregnant women * no anatomical alteration of fetus * no genetical abnormality of fetus

Locations (1)

Universitiy of Szeged

Szeged, Hungary

Outcomes

Primary Outcomes

Maternal characteristics (BMI)

The pre-pregnancy body mass index (BMI) registered at the initial visit during prenatal care was calculated as the body weight (kg) per height (m2).

Time frame: through study completion, 2 years

Neonatal outcome 1; based on gestational age

The participants were recorded by gestational age et birth