RATIONALE: Colorectal cancer is one of the most common cancers. However, approaches to minimize surgical trauma, preserve anal function, avoid abdominal stoma, and improve quality of life for patients with ultralow rectal cancers were limited. Thus, new technologies are urgently needed to improve the anal preservation rate, reduce the incidence of anastomotic leakage and improve postoperative anal function in patients with ultralow rectal cancer. PURPOSE: This one-arm multicenter prospective cohort study aims to collect the data of patients with ultralow rectal cancer who undergo sphincter-preserving surgeries, including modified PPS and conventional surgeries, then compare the effects of different operations on clinical outcomes and to see the efficacy and safety of modified PPS surgery when compared with conventional procedures in the treatment of ultralow rectal cancer.
Study Type
OBSERVATIONAL
Enrollment
120
Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGRate of temporary defunctioning stoma
The percentage of patients who get temporary defunctioning stoma to limit the consequences of anastomotic leakage.
Time frame: Within 30 days after operation
The percentage of patients who develop anastomotic leakage
The percentage of patients who develop anastomotic leakage
Time frame: Within 30 days after operation
Postoperative anal function assessed by Wexner scale
Ranging from 0 (perfect continence) to 20 (complete incontinence)
Time frame: 2 years since the start of treatment
Postoperative anal function assessed by Vaizey scale
Ranging from 0 (perfect continence) to 24 (complete incontinence)
Time frame: 2 years since the start of treatment
Rate of sphincter-preservation rates
The percentage of patients who preserve the anatomical structure of the anus
Time frame: Within 30 days after operation
The number of short-term postoperative complications
The number of grade II and higher postoperative complications according to the Clavien-Dindo classification
Time frame: Within 30 days after operation
Postoperative hospital stay
The time between the operation date and the discharge date.
Time frame: Within 30 days after operation
Hospitalization costs
The total cost of hospitalization
Time frame: Within 30 days after operation
30-Day Readmission Rate
Percentage of readmitted patients within 30 days after operation
Time frame: Within 30 days after operation
Disease-free survival
Disease-free survival is defined as the time from surgery to recurrence of tumor or death
Time frame: Up to 5 years after the last patient recruited
Overall survival
Overall survival is defined as the time from surgery until death from any cause.
Time frame: Up to 5 years after the last patient recruited
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