This is a pivotal study to investigate absorption of inhaled tiotropium from 2 Tiotropium Easyhaler product variants and Spiriva capsules inhaled via HandiHaler.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
88
In each period, subjects receive single dose of tiotropium consisting of 2 inhaled doses via Easyhaler or 2 Spiriva capsules inhaled via HandiHaler
Clinical Pharmacology Unit, Orion Corporation
Espoo, Finland
Peak tiotropium concentration in plasma (Cmax)
Time frame: between 0-72 hours after dosing
Area under the concentration-time curve from time zero to 30 minutes (AUC30 minutes)
Time frame: between 0-30 minutes after dosing
Area under the concentration-time curve from time zero to 72 hours (AUC72 hours)
Time frame: between 0-72 hours after dosing
Time to reach peak concentration in plasma (tmax)
Time frame: between 0-72 hours after dosing
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