This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.
Postoperative impairment of liver function is common after hepatectomy. It may be caused by surgical trauma, loss of hepatic mass, stress response, hepatic oxygen deprivation, infection and drug toxicity. Anesthetic agents used in general anesthesia for liver surgery have a big effect on hepatic blood flow, oxygen delivery and liver function This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
30
Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine.
Patients will receive maintenance of general anesthesia by desflurane.
Ain Shams University
Cairo, Egypt
RECRUITINGaspartate aminotransferase (AST)
aspartate aminotransferase (AST)
Time frame: 1 week
alanine aminotransferase (ALT)
alanine aminotransferase (ALT)
Time frame: 1 week
bilirubin
bilirubin
Time frame: 1 week
albumin
albumin
Time frame: 1 week
prothrombin time
prothrombin time
Time frame: 1 week
INR
INR
Time frame: 1 week
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