Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases.
Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases. All participants will be recruited from Zhongshan Ophthalmic Center, Sun Yat-sen University and Affiliated Foshan Maternity \& Child Healthcare Hospital, Southern Medical University. Only children with written informed consent from their parents can participate in this study. Participants will be excluded for (1) age\>18; (2) previous use of orthokeratology lenses or low-concentration atropine; (3) allergy to compound tropicamide eye drop; (4) any history of ocular surgery. All participants will undergo optometry and biometric measurements by a trained team. The axial length (AL), central corneal thickness (CCT), anterior corneal radii of curvature, anterior chamber depth (ACD), lens thickness (LT), the curvature power of the central flat meridian (K1) and the central steep meridian (K2), the ocular surface and fundus will be measured. All measurements will be taken in room light condition (1000 lux).
Study Type
OBSERVATIONAL
Enrollment
1,000
change of the non-invasive tear break-up time
change of the non-invasive tear break-up time in seconds
Time frame: baseline, 24th months
change of the lipid layer of tear film
change of the lipid layer of tear film in nanometers
Time frame: baseline, 24th months
vision
spherical equivalent in diopters
Time frame: baseline, 6th months, 12th months, 18th months, 24th months
intraocular pressure
the intraocular pressure in mm Hg
Time frame: baseline, 6th months, 12th months, 18th months, 24th months
Eye axis length
Eye axis length in millimeters
Time frame: baseline, 6th months, 12th months, 18th months, 24th months
Anterior chamber depth
Anterior chamber depth in millimeters
Time frame: baseline, 6th months, 12th months, 18th months, 24th months
central corneal thickness
central corneal thickness in millimeters
Time frame: baseline, 6th months, 12th months, 18th months, 24th months
Lens thickness
Anterior chamber depth in millimeters
Time frame: baseline, 6th months, 12th months, 18th months, 24th months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Retina thickness
retina thickness in millimeters
Time frame: baseline, 6th months, 12th months, 18th months, 24th months
choroid thickness
choroid thickness in millimeters
Time frame: baseline, 6th months, 12th months, 18th months, 24th months
Corneal curvature
Corneal curvature in diopters
Time frame: baseline, 6th months, 12th months, 18th months, 24th months
non-invasive tear break-up time
non-invasive tear break-up time in seconds
Time frame: 6th months, 12th months, 18th months
the lipid layer of the tear film
the lipid layer of the tear film in nanometers
Time frame: 6th months, 12th months, 18th months