This multicenter, randomized controlled trial will compare the use of NGS and traditional culture in directing antimicrobial treatment for patients with periprosthetic joint infection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
250
Medications to treat prosthetic joint infection will be chosen based on results of traditional cultures alone
Medications to treat prosthetic joint infection will be chosen based results of NGS and culture
University of Southern California
Los Angeles, California, United States
Cleveland Clinic Florida
Weston, Florida, United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States
Columbia University
Number of participants who have been diagnosed with prosthetic joint infection as assessed by the 2018 International Consensus Definition of prosthetic joint infection
Diagnosis of re-infection following surgery and treatment for prosthetic joint infection
Time frame: 90 days from time of surgery
Number of subjects who have a re-operation as assessed by inpatient hospitalization medical records
Time frame: one year from time to surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
New York, New York, United States
University of Rochester
Rochester, New York, United States
Northwell Health
Staten Island, New York, United States
Cleveland Clinic Ohio
Cleveland, Ohio, United States
Rothman Orthopaedic Institute
Philadelphia, Pennsylvania, United States
University of Utah
Salt Lake City, Utah, United States