Effect of Food on PC14586 in Healthy Volunteers and the PK of PC14586 in Healthy Japanese Volunteers

Inclusion Criteria: * Healthy, non-smoking male and female Caucasian/ non-Asian or Japanese human volunteers * 18 to 55 years of age * Able to swallow tablets. Inclusion criteria for Japanese participants only: * Japanese and born in Japan (1st generation) * The parents and grandparents of the participant are ethnically Japanese and born in Japan * Has undergone no significant change in lifestyle since leaving Japan * Has lived \< 10 years outside of Japan Exclusion Criteria: * Clinically significant medical history as determined by the PI. * Any disorder that would interfere with the absorption, distribution, metabolism or excretion of drugs. * A p53 Y220C mutation. * Blood pressure \>140 mm systolic or \>90 diastolic. * Smoked or used other nicotine-containing products during the previous 3 months. * History of alcohol and/or illicit drug abuse within the previous 5 years. * Hepatitis B surface antigen (HBsAg), Hepatitis C antibody or human immunodeficiency virus (HIV). * Positive blood test for ethanol. * Positive urine drug test. * Pregnancy or breastfeeding. * Unwilling to avoid use of alcohol or alcohol-containing foods, medications or beverages, within 48 hours prior to admission until discharge from the clinical site. * Has donated blood within 2 months prior to admission. * Has used over-the-counter (OTC) medications (including vitamins), prescription medications or herbal remedies from 14 days prior to admission. * Has used an investigational drug within 30 days prior to Screening.