Evaluation of Infective Risk, Efficacy of Bacterial Prophylaxis and Validation of Sepsis Scores NEWS (National Early Warning Score) and qSOFA (Quick Sequential Organ Failure Assessment) in Patient With Acute Myeloid Leukemia Treated With Intensive Chemotherapy

Systemic Inflammatory Response Syndrome (SIRS) development

Ability of NEWS and qSOFA score to predict SIRS development calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve)

Time frame: At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline

Amine requirement

Ability of NEWS and qSOFA score to predict vasoactive drugs requirement calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve)

Time frame: At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline

Respiratory failure

Ability of NEWS and qSOFA score to predict respiratory failure calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve)

Time frame: At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline

Ventilation support

Ability of NEWS and qSOFA score to predict ventilation support necessity calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve)

Time frame: At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline

Intensive care unit (ICU) admission

Ability of NEWS and qSOFA score to predict ICU admission calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve)

Time frame: At baseline (fever onset), change at 24 hours from baseline, change at 48 hours from baseline

Bloodstream infections

Ability of NEWS and qSOFA score to predict severity of bloodstream infection calculating the area under the ROC (receiver operating characteristics) curve called AUROC (area under the ROC curve)

Time frame: From date of fever onset until the date of fever resolution, assessed up to 60 days

Number of infections

Cumulative incidence of infections in patients with levofloxacin prophylaxis vs. patients without levofloxacin prophylaxis

Time frame: From date of neutrophils count <500/mmc until the day of neutrophils count >=500/mmc, assessed up to 60 days