Macular Pigment Optical Density in Primary Angle-closure Disease

Zhongshan Ophthalmic Center, Sun Yat-sen University60 enrolled

Overview

Glaucoma is the leading cause of irreversible blindness in the world, and primary angle-closure glaucoma (PACG) is the most important type of glaucoma in Asia. Primary angle closure disease (PACD) is a group of diseases related to PACG, and the pathogenesis is still unclear. Macular pigment has the functions of filtering short-wavelength waves and anti-oxidation, which are related to visual function. Previous studies have found that the macular pigment density (MPOD) is significantly reduced in primary open-angle glaucoma. This project uses the single-wavelength reflection method to measure MPOD, observes the characteristics of PACD and the normal control group's changes in retinal MPOD, and explains the relationship between PACD's MPOD changes and angle-closure glaucoma optic nerve damage

Observation index： Visual acuity，Intraocular pressure，Ophthalmoscope，MPOD，Visual field and OCT. Inspection parameters of OCT： 1. Retinal nerve fiber layer thickness 2. Ganglion cell complex thickness 3. Mean thickness of the central retina 4. Mean defect

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glaucoma Glaucoma, Angle-Closure Macular Pigment Optical Density

Interventions

Eligibility

Sex: ALLMin age: 40 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Experimental group： * (1) According to the diagnostic criteria of PACD * (2)History of peripheral iridectomy or trabeculectomy * (3)Over 40 * (4)Phakic eyes * (5)Intraocular pressure is less than 21mmhg, more than one week * (6)Eyes with clear optical media. * Control group： * (1)No history of glaucoma and other eye diseases * (2)Phakic eyes * (3)Over 40 * (4)Intraocular pressure10\~21mmHg Exclusion Criteria: * (1)History of corneal diseases * (2)History of eye tumor or other ophthalmic surgery * (3)Cataract * (4)Taking supplements containing lutein within 6 months * (5)Snellen's visual acuity was less than 6 / 20，the diopter is beyond ± 6 degrees

Outcomes

Primary Outcomes

Macular Pigment Optical Density（MPOD）Measurement

A one-wavelength fundus reflectance method (Visucam 200; Carl Zeiss Meditec) was used for the detection of MPOD as previously described. The right or left eye was randomly selected for measurement. The parameters and profiles of MPOD in a 7-degree eccentricity that corresponded to a 4 mm diameter were evaluated and output. Parameters included max and mean optical density (OD), volume, and area. MaxOD and MeanOD with units "d.u." (initial of density units) were used for the analyses.