Transcranial Direct Stimulation for Persistent Fatigue Treatment Post-COVID-19

Hospital San Carlos, Madrid47 enrolled

Overview

Fatigue is common and disabling in patients with post-COVID syndrome. There is no treatment available at this moment, and fatigue has important consequences. The main aim of this study is to evaluate the changes in the severity of fatigue using non-invasive neuromodulation in patients with post-COVID condition. This is a randomized, parallel, double-blind, placebo-controlled clinical trial using transcranial direct current stimulation. Secondary aims include changes in cognition, depression, and quality of life.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

COVID-19

Interventions

Active tDCSDEVICE

Eight sessions of transcranial current direct stimulation

Sham tDCSDEVICE

Eight sessions of transcranial current direct stimulation (sham)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of COVID-19 with PCR-confirmation. * Fatigue linked to COVID-19 * No diagnosis of neurological, psychiatric or medical disorder with potential impact on fatigue. Exclusion Criteria: * Stroke before COVID-19 * History of traumatic brain lesion or central nervous system infection previous to COVID-19 * Radiotherapy or chemotherapy for cancer * Severe sensorial deficits * Drugs or uncontrolled medical disorder with potential impact on fatigue. * History of abuse of alcohol or other toxics. * Any contraindication for tDCS (metallic implants, brain devices, pacemakers, head injuries).

Locations (1)

Hospital Clínico San Carlos.

Madrid, Spain

Outcomes

Primary Outcomes

Change in Fatigue

Modified Fatigue Impact Scale (MFIS)

Time frame: 2 weeks

Secondary Outcomes

Change in cognition

Stroop Test

Time frame: 2 weeks

Change in depressive symptoms

Beck Depression Inventory II

Time frame: 2 weeks

Change in quality of life

EuroQuol-5D

Time frame: 2 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.