Levels of Pigment Epithelium-derived Factor in Patients With Psoriasis.

Sohag University52 enrolled

Overview

Psoriasis is an immune-mediated chronic inflammatory skin disease associated with increase interaction of inflammatory mediators like adipokines. Pigment epithelium-derived factor (PEDF) is one of the most abundant adipokines and have anti-angiogenesis effect. There is a study showed that PEDF level is up-regulated in the sera of psoriasis patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

DOUBLE

Enrollment

Conditions

Psoriasis

Interventions

serum samples and punch skin biopsiesOTHER

we will take serum samples from psoriasis patients and healthy controls and skin punch biopsies from lesional and non-lesional areas in psoriasis patients.

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Patients with psoriasis and group of age and sex-matched healthy volunteers will be included as a control group. Exclusion Criteria: * Pregnancy. * Patients with other inflammatory skin disorders. * Patients on antioxidants or anti-inflammatory drugs. * Patients on topical or systemic treatment for psoriasis in the last 4 weeks prior to enrollment in the study. * Patients on systemic retinoids (Acitretin). * Obesity: body mass index (BMI ) \> 30. * Malignancies e.g squamous cell carcinoma. * Viral warts. * Diabetes. * Hypertension.

Locations (1)

Faculty of Medicine Sohag University

Sohag, Egypt

RECRUITING

Outcomes

Primary Outcomes

changes in serum and tissue levels of (PEDF) in patients with psoriasis

evaluate serum and tissue level of (PEDF) in patients with psoriasis.

Time frame: 12 months

Central Contacts

Omnia Ahmed, Resident of Dermatology

CONTACT

01064292851 omnia.mohamed1@med.sohag.edu.eg

Data from ClinicalTrials.gov

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