A Stool DNA-based SDC2 Methylation Test for the Early Detection of Colorectal Cancer

Inclusion Criteria: Subjects enrolled into the study must meet the following criteria: * Individuals who agree to voluntarily sign an informed consent prior to the initiation of screening * Adults aged ≥ 40 years * Subjects who are at high-risk (Asia Pacific Colorectal Screening (APCS) Score: 4.0\~7.0) of developing CRC * Subjects who are able and willing to undergo colonoscopy screening within 12 months of consent among individuals who reserved a visit in the division of gastroenterology or health check-up. Exclusion Criteria: Subjects will be excluded from enrolling into the study if any of the following criteria are met: * Individuals who do not agree to voluntarily sign an informed consent prior to the initiation of screening * Adults aged \< 40 years * Subjects who are not at high-risk (APCS Score ≤ 3.0) of developing CRC * Subjects who will not undergo colonoscopy screening within 12 months of consent * Subjects who have had a positive FIT or fecal occult blood test within the previous 2 weeks * Colorectal cancer patients who did not underwent curative treatment * Subjects who have had a prior history of colorectal resection * Subjects who have had overt rectal bleeding or melena within the previous 2 weeks * Subjects who have a family history or a prior history of hereditary CRC or colorectal neoplasm: Lynch syndrome (HNPCC), familial adenomatous polyposis, MUTYH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers syndrome, and serrated polyposis syndrome, etc. * Subjects who have inflammatory bowel diseases including Crohn's disease, ulcerative colitis or Behcet disease * Subjects who participated in any "interventional" clinical study within the previous 30 days * Subject has any condition which, in the opinion of the medical staff should preclude participation in the study