Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
CoVAPid2 is a multicenter retrospective observational cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic. Patients with confirmed SARS-CoV-2 community-acquired pneumonia and receiving invasive mechanical ventilation for more than 48h in the participating ICUs from the start of COVID pandemic are eligible for this study. Consecutive patients will be included from the beginning of the first wave (starting on 01-01-2020, data already collected in the CoVAPid1 study) and the second wave (starting on 10-01-2020). 10-20 patients per wave will be included in each center. VAT and VAP are defined using clinical, radiological and quantitative microbiological criteria.
Study Type
OBSERVATIONAL
Enrollment
1,136
Hop Salengro - Hopital B Chr Lille
Lille, France
RECRUITINGCumulative incidence of ventilator-associated lower respiratory tract infection (ventilator-associated pneumonia and ventilator associated tracheobronchitis)
Time frame: from day 3 of mechanical ventilation to extubation or day 28 post-intubation
Cumulative incidence of ventilator-associated tracheobronchitis
Time frame: from day 3 of mechanical ventilation to extubation or day 28 post-intubation
Cumulative incidence of ventilator-associated pneumonia
Time frame: from day 3 of mechanical ventilation to extubation or day 28 post-intubation
Prevalence of early bacterial coinfection
Time frame: from day 0 to day 2 of mechanical ventilation
Cumulative incidence of COVID-associated pulmonary aspergillosis
Time frame: from day 3 of mechanical ventilation to extubation or day 28 post-intubation
ICU mortality
Time frame: at day 28
Mortality
Time frame: at day 28
Duration of mechanical ventilation (number of days under mechanical ventilation)
Time frame: from the start of mechanical ventilation to extubation or day 28 after intubation
Duration of ICU stay (number of days in the ICU)
Time frame: from the ICU admission to discharge or day 28 after admission
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